We need to translate Russian news post into natural English, format per rules.
First line: short headline under 90 chars, no markdown. Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines.
We need to wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks. At most 4-5 per post. Also wrap study/journal citations and publication references in single underscores.
We must preserve all facts, numbers, names, citations exactly. No commentary.
We need to decide which facts to bold: likely the headline may contain some but we need to limit bold to 4-5 total in the post. We'll choose key numbers: 97% editing, 33% average, 25% editing in liver, 34% PCSK9 reduction, 36% large deletions. Also maybe date: 24 August in Nature Biotechnology. Also maybe mention EvoMax cycle. But we need at most 4-5 bolded items. Let's pick: 97%, 33%, 25%, 34%, 36% (that's five). Also we could bold gene names? But that would increase count. We'll keep to those five percentages.
We need to wrap study/journal citations in single underscores: e.g., Nature Biotechnology, August 24, 2026? The original says: "24 августа в Nature Biotechnology вышла статья о EvoMax". So we need to wrap that citation: Nature Biotechnology, August 24, 2026 (or similar). Also maybe mention "В материале о Cas9d Ultra описан другой компактный редактор". That is not a citation but a reference; we could treat as a reference but not needed. We'll just underscore the Nature Biotechnology citation.
We need to ensure we don't bold whole sentences, only the numbers.
We need to keep the text natural, short paragraphs 2-3 sentences each.
Let's draft translation.
Headline: something like "EvoMax improves compact Fanzor2 DNA editor, shows high editing but toxicity in mice". Must be under 90 chars. Count: "EvoMax improves compact Fanzor2 DNA editor, shows high editing but toxicity in mice" length approx 78. Good.
Now blank line.
Paragraph 1: talk about EvoMax cycle, article date, Fanzor2 compact editor, guide RNA, AAV packaging.
We need to embed bold numbers where appropriate. In paragraph 1 maybe no numbers yet.
Paragraph 2: talk about prior low editing, need for large libraries, EvoMax used 209 measurements, three cycles testing 10-20 variants each.
Paragraph 3: mention modifications: shortened/stabilized guide RNA, fused human La protein, yielding FanzMAX v3-hLa.
Paragraph 4: editing efficiency in human cell mix: up to 97% at best site, average ~33% across 19 sites.
Paragraph 5: test in mouse liver with human PCSK9 gene; AAV 1.0 gave ~25% editing, reduced PCSK9 blood level 34% without toxicity.
Paragraph 6: two stronger configurations caused acute toxicity and death 7-14 days; AAV 3.0 led to large deletions >30 bp in 36% of edited reads.
Paragraph 7: mention Cas9d Ultra comparison, similar editing ranges but different repair mechanisms.
Paragraph 8: note that in AAV configurations varied Fanzor2 variant, La protein, guide RNA, vector elements; next version choice depends on editing fraction, post-repair outcomes, tissue response.
We need to bold numbers: 97%, 33%, 25%, 34%, 36%. Also maybe the date? But we limited to five. We'll bold those percentages.
We need to ensure each bolded number is wrapped in .
Also need to underscore the citation: Nature Biotechnology, August 24, 2026.
Let's embed.
Paragraph 1: "EvoMax improved the compact Fanzor2 DNA editor; the work was described in a Nature Biotechnology, August 24, 2026 article. Authors used Fanzor2, a small protein that, guided by RNA, cuts a chosen DNA site. Its small size lets both editor and guide RNA fit into a single AAV vector."…
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Nature
Adaptive model-guided protein evolution with sparse data optimizes compact eukaryotic genome editors
Nature Biotechnology - Computational protein evolution with sparse data generates efficient small RNA-guided nucleases.
August 26, 2026 3
