We need to translate Russian news post into natural fluent English, format per rules.
We need a short headline under 90 chars, no markdown, first line only.
Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines.
We need to wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence.
Wrap study/journal citations and publication references in single underscores _ (e.g., Nature Aging, July 2026).
We must preserve all facts, numbers, names, citations exactly. No added commentary.
We need to identify citations: The text mentions "21 августа в эссе об органоидах сопоставили две задачи." That's a date: August 21 (year unspecified). Also "В работе 2013 года описан FIS-тест". So citation: work 2013 year. Also "В работе на восьми редких вариантах CFTR результаты FIS сопоставили с ответом на модификаторы CFTR: шесть участников начали терапию, а авторы зафиксировали рост функции лёгких и снижение хлорида в поте." That's a study but not given journal name. Might need to treat as citation? The rule: wrap study/journal citations and publication references in single underscores. So we need to put something like 2013 work? But we need to preserve exactly the citation as given. The Russian says "В работе 2013 года описан FIS-тест". That is a reference to a work from 2013. We can wrap "2013 года" maybe? But we need to keep the fact. Probably we should wrap the year in double asterisks as a key number? Actually numbers: 2013, six patients, eight rare variants, 256 tumor organoids, six patients started therapy, etc. We need to select at most 4-5 double asterisk facts.
Important facts: date August 21 (maybe year unknown), six patients with metastatic colorectal cancer, tumor organoid test didn't shrink tumor in any, six patients started therapy (CFTR), eight rare CFTR variants, 256 tumor organoid bank, maybe also "FIS-test" but that's a method name not a number.
We need to be selective: maybe choose: August 21, six patients, eight rare CFTR variants, 256 tumor organoids, six patients started therapy. That's five.
Now we need to wrap study/journal citations in single underscores. The text mentions "В работе 2013 года описан FIS-тест". Could treat that as a citation: work 2013. Also maybe "В работе на восьми редких вариантах CFTR". Could treat as study on eight rare CFTR variants. But we need to preserve exactly the citation as given? The rule: wrap study/journal citations and publication references in single underscores (e.g., Nature Aging, July 2026). So we need to identify any explicit citation like a journal name. There's none besides "работа 2013 года". That's not a journal but a work. We could still wrap "2013 года" maybe? But that's a date, already double asterisk? Might conflict. Better to treat the phrase "В работе 2013 года" as a citation and wrap whole phrase in single underscores? But that would include Russian text; we are translating to English, so we need to translate the content but keep the citation reference. So we could translate as "work from 2013" or "study 2013". But we must preserve facts exactly; we can translate but keep the meaning. The rule says preserve all facts, numbers, names and citations exactly. So we need to keep the citation exactly as it appears? The original Russian: "В работе 2013 года описан FIS-тест". If we translate, we need to keep the fact that it's a 2013 work describing FIS test. We could render as "work from 2013". That preserves the fact (2013) and the nature (work). It's not exactly the same string but the fact is preserved. Probably acceptable.…
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PubMed Central (PMC)
Prospective experimental treatment of colorectal cancer patients based on organoid drug responses
Organoid technology has recently emerged as a powerful tool to assess drug sensitivity of individual patient tumors in vitro. Organoids may therefore represent a new avenue for precision medicine, as this circumvents many of the complexities ...
August 26, 2026 4
