We need to translate Russian news post into English, format per rules.
First line: short headline under 90 chars, no markdown, no '#'.
Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines.
Wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence.
Wrap study/journal citations and publication references in single underscores _ (e.g., Nature Aging, July 2026).
We need to preserve all facts, numbers, names, citations exactly. No commentary.
We need to identify citations: The Russian text mentions: "Открытый обзор описал три маршрута к выращиванию человеческих клеток и органов в животных 24 августа вышел открытый обзор о животных-биореакторах." So there is an open review published Aug 24 (year not given). Probably 2024? Not specified. We'll keep date as given: 24 августа (August 24). No year. We'll keep as "August 24". Might need to keep as "24 августа". We'll translate to "August 24". No year.
Then mentions: "Принцип сработал в опыте 2010 года." So year 2010.
Then: "В работе 2020 года у эмбрионов свиньи отключили ген ETV2..." So 2020.
Then: "В работе 2023 года человеческие клетки ввели в эмбрионы свиньи..." So 2023.
Thus we have dates: 2010, 2020, 2023, August 24 (maybe 2024). Also gene names: ETV2. Also maybe mention of "blastocyst complementation". Also mention of "плюрипотентные клетки" (pluripotent cells). Also mention of "мезонефроса" (mesonephros). Also mention of "органогенная ниша". Also mention of "животное-биореактор". Also mention of "клетки крови". Also mention of "печени". Also mention of "почки, сердце или печень". Also mention of "клетки печени или крови". Also mention of "донорские плюрипотентные клетки". Also mention of "крысиной поджелудочной". Also mention of "крысиной поджелудочной железы". Also mention of "крысиной поджелудочной". Also mention of "крысиной поджелудочной". Also mention of "крысиной поджелудочной". Also mention of "крысиной поджелудочной". Ok.
We need to wrap key numbers, percentages, drug/company/gene names, dates in double asterisks. At most 4-5 per post. So we need to select maybe 4-5 important facts: dates (2010, 2020, 2023, August 24) and gene name ETV2. That's 5. Could also include "мезонефроса" but that's not a number or gene. Could include "крысиной поджелудочной" but that's not a number. So we will bold: 2010, 2020, 2023, August 24, ETV2. Ensure not whole sentence.
Now citations: The text mentions "открытый обзор" but not a journal name. It mentions "работа 2020 года", "работа 2023 года". No journal names given. So we may not have any citation to wrap in underscores. However we could treat "открытый обзор" as a publication reference? Not sure. The instruction: "Wrap study/journal citations and publication references in single underscores (e.g. Nature Aging, July 2026)." Since we don't have explicit journal names, maybe we don't need any underscores. But we could treat "открытый обзор" as a publication reference? It's not a journal. Safer to leave none.
Now formatting: First line headline under 90 chars. Let's craft: "Open Review Outlines Three Strategies for Growing Human Organs in Animal Bioreactors". Count characters: Let's count: O(1) ... Let's just ensure <90. It's fine.
Then blank line.
Then body paragraphs, each 2-3 sentences.
We need to split the content logically.
Paragraph 1: Introduce the review published Aug 24, describing three routes: whole organ assembly, directing cells to specific tissue, multiplying cellular product.
Paragraph 2: Explain blastocyst complementation: host embryo gene knocked out, donor pluripotent cells fill niche, example 2010 mouse pancreas with rat cells.
Paragraph 3: Discuss vascular lineage importance, 2020 pig embryo ETV2 knockout, human iPSC endothelial cells all human by day 17-18.…
🔗 Read original →
Nature
The making of cells and organs in xenogeneic animal bioreactor
Signal Transduction and Targeted Therapy - The making of cells and organs in xenogeneic animal bioreactor
August 26, 2026 4
