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BW, a 45-year-old man, 5' 12" tall, weighing 92 kg, is admitted to the hospital for a right colectomy because of colon cancer. Initially, he has normal renal function: serum creatinine concentration of 1.00 mg/dL. He subsequently developed a postoperative wound infection, which is treated with surgical drainage and an intravenous cephalosporin. Culture of the wound fluid reveals methicillin-resistant Staphylococcus aureus, with a vancomycin MIC < 1. As a Pharmacist you are consulted for vancomycin dosing for BW.
Due to nurse shift; plasma concentrations of 30 mg/L a concentration drawn 2 hours after the end of a 1-hour infusion if desired trough concentration was approximately 14 mg/L.
