Cryoprotectant penetrates fixed human brain over nine months
On 24 August PLOS One published a protocol for storing whole human brains at −20 °C after chemically fixing their cellular structure. The goal was to assess how a cryoprotectant solution diffuses through the tissue and whether fine structure survives cooling, storage, and rewarming.
Brains were first fixed with a cross‑linking agent to lock in tissue architecture after death.
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PubMed Central (PMC)
Cryopreservation of brain cell structure: a review
Cryopreservation, the preservation of tissues at subzero temperatures, is a mainstay of brain banking that allows for the storage of brain tissue without the use of chemical fixatives. This is particularly important for molecular studies that are ...
