Data-driven discovery of associations between prescribed drugs and dementia risk: A systematic review
Highlights
·We present a systematic review of studies reporting association between drugs prescribed for other conditions and risk of dementia including 139 million people and 1 million cases of dementia.
·Our work supports some previously reported associations, for example, showing decreased risk of dementia with drugs to treat inflammatory disease and increased risk with antipsychotic treatment.
·Antimicrobial treatment was perhaps more surprisingly associated with decreased risk, supportive of recent increased interest in this potential therapeutic avenue.
·Our work should help prioritize drugs for entry into adaptive platform trials in Alzheimer's disease and will serve as a useful resource for those investigating drugs or classes of drugs and risk of dementia.
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70037
https://t.me/ToBeResearcher
2January 22, 2025 730 3
