Associations between different coffee types, neurodegenerative diseases, and related mortality: findings from a large prospective cohort study
Background
Observational studies have suggested associations between amount of coffee consumption and decreased risk of neurodegenerative diseases. However, these studies do not consider differences among coffee types, including sweetened, unsweetened, caffeinated, and decaffeinated varieties.
Objectives
This study aims to identify associations between the consumption of various coffee types (sugar-sweetened, artificially sweetened, unsweetened, caffeinated, and decaffeinated) and risks of Alzheimer’s disease and related dementias (ADRD) and Parkinson’s disease (PD), along with related mortality.
Methods
This prospective study included 204,847 participants (44.7% males) from the UK Biobank. Cox proportional hazards models were used to assess the associations of coffee type with neurodegenerative outcome. On the basis of coffee consumption, participants were divided into 5 groups: non-coffee consumers, >0–1 cup/d, ≥1–2 cups/d, ≥2–3 cups/d, and ≥3 cups/d.
Results
Over a median follow-up of 9 y, the study documented 1696 cases of ADRD, 1093 cases of PD, and 419 neurodegenerative-related deaths. In the multivariate analysis, compared with non-coffee consumers, those with the highest intake of unsweetened and caffeinated coffee (≥3 cups/d) showed hazard ratios (95% confidence intervals) of 0.75 (0.62, 0.91) for ADRD, 0.71 (0.56, 0.91) for PD, and 0.67 (0.44, 1.01) for neurodegenerative-related death. However, no significant associations were noted in either decaffeinated or sugar/artificially sweetened coffee groups (P > 0.05).
https://www.sciencedirect.com/science/article/abs/pii/S0002916524006713
https://t.me/ToBeResearcher
Telegram
ToBeResearcher
A channel to:
⭕Dive into research,
⭕Learn how to design a new study,
⭕Be up-to-date about recent findings in the field,
⭕Say hi to new co-workers :))
Admin:
https://scholar.google.com/citations?user=iXBkjv0AAAAJ&hl=en
@toberesearcher2
January 20, 2025 246 1
