#مقاله_های_کالج_بیوانفورماتیک
Association of item-level responses to cognitive function index with tau pathology and hippocampal volume in the A4 Study, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://doi.org/10.1002/dad2.70128
Alzheimer's disease (AD) has a long preclinical phase in which individuals may accumulate amyloid beta (Aβ) and tau pathology without noticeable cognitive impairment. Subjective cognitive impairment reports can provide early insights into cognitive decline.
In the A4 Study, 339 cognitively unimpaired, Aβ-positive individuals underwent tau positron emission tomography imaging. Tau status was classified based on medial temporal lobe tau standardized uptake value ratios (tauMTL). Participants and study partners assessed cognitive changes using the 15-item Cognitive Function Index (CFI) questionnaire. We explored the relationship among tauMTL, hippocampal volume (HVa), and CFI reports.
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