In a recent study published in the Federation of American Societies… — Swasthavritta - preventive and social medicine — TG.ME

In a recent study published in the Federation of American Societies for Experimental Biology (FASEB) journal, researchers evaluate the effects of body mass index (BMI) on physical activity (PA)- and muscle/hand-grip strength-induced intestinal microbiome compositional alterations among middle-aged adult individuals.Background Lack of physical exercise is associated with increased morbidity and mortality. In fact, PA is associated with various preventative and therapeutic health effects against inflammatory and cardiometabolic diseases. Regular PA results in metabolic adaptations such as altered intestinal microbiota composition. Intestinal microbial dysbiosis influences weight by altered energy utilization from dietary sources. In addition, the symbiotic relationship between the host and intestinal microbiome optimizes lipid and glucose metabolism and immunological responses against inflammation. Calorie-dense diets alter intestinal microbiota composition and functions by reducing the abundance and diversity of beneficial microbes such as Roseburia, Bifidobacterium, and Faecalibacterium. Comparatively, PA has been shown to increase beneficial microbe abundance and reduce pathogenic microbe counts, leading to increased short-chain-type fatty acid (SCFA) levels and enhanced lactate utilization. However, the effects of regular PA on intestinal microbiome composition have not been well-characterized, as most previous studies comprised athletes consuming strict diets and participating in rigorous exercise training. About the study In the present study, researchers investigate whether alterations in intestinal microbiota composition by physical activity and hand-grip strength were affected by BMI values. The study cohort included individuals with normal BMI values within the range of 19 and 25 kg/m2 and those with elevated BMI values between 25 and 30 kg/m2.

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