Correct Answer - A Ans: A. Thiazide increases the tubular absorption… — Pharmacology

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PharmacologyA patient on lithium therapy developed hypertension. He was started on Thiazide for hypertension. After a few days, he developed coarse tremors and other symptoms suggestive of lithium toxicity. What is the probable mechanism of interaction?

Correct Answer - A
Ans: A. Thiazide increases the tubular absorption of lithium
Drug Interaction:
Diuretics + Lithium = Decreased excretion—rise in Li + level -
toxicity;
Diuretics (thiazide, furosemide) by causing Na + loss to promote
proximal tubular reabsorption of Na + as well as Li + → plasma
levels of lithium rise. Potassium-sparing diuretics cause milder Li +
retention.
Management: Reduce dose of lithium and monitor level.

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