Correct Answer - A
Ans. A. 21 alpha-hydroxylase
The condition described above represents the Congenital adrenal
hyperplasia.
"More than 90% of CAH cases are caused by 21-hydroxylase
deficiency"
Congenital adrenal hyperplasia:
It is due to an inborn error of adrenal steroid metabolism, commonly
due to 21-hydroxylase (95%) and rarely due to 11-hydroxylase or 3β
hydroxysteroid dehydrogenase deficiency.
Clinical presentation
An ambiguity of sex at birth
Hirsutism and amenorrhea may be the presenting features around
puberty in a milder form.
The karyotype is 46, XX.
Ref. Dutta Gynaecology ed. 6th page no. 440
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