امسكيو عن الملزمة المظافة:
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1. Which of the following is TRUE regarding IV administration of protein drugs?
A. Always achieves the desired concentration–time profile
B. Is the only suitable route for LH-RH administration
C. May not always provide the desired concentration–time profile
D. Is more convenient than oral administration
Answer: C
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2. One reason why SC or IM injection might be preferred over IV for LH-RH is:
A. Greater bioavailability
B. More rapid systemic circulation
C. Mimics natural pulsatile hormone release
D. Avoids presystemic degradation
Answer: C
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3. A major limitation of SC and IM administration is:
A. Rapid absorption
B. Protein aggregation
C. Presystemic degradation
D. High permeability
Answer: C
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4. Compared to IV administration, SC and IM routes often show:
A. Increased bioavailability
B. No degradation
C. Delayed immune response
D. Reduced bioavailability
Answer: D
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5. Protein aggregation is challenging because it involves:
A. Simple chemical instability
B. Linear temperature effects
C. Complex aggregation mechanisms and temperature-dependent stability
D. Immediate immune rejection
Answer: C
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6. Which statement about molecular weight and lymphatic absorption is TRUE?
A. Smaller proteins are absorbed more by lymphatics
B. There is no relationship
C. Lymphatic absorption decreases with molecular weight
D. Lymphatic absorption increases with molecular weight
Answer: D
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7. Oral administration of protein drugs is desirable because:
A. It has high systemic bioavailability
B. It reduces production costs
C. It is convenient, cost-effective, and painless
D. It prevents enzymatic degradation
Answer: C
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8. The disposition of peptide and protein drugs can often be predicted by:
A. Their half-life
B. Their solubility
C. Their physiological function
D. Their formulation type
Answer: C
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9. A major challenge for oral peptide/protein drugs is:
A. Low plasma binding
B. High lipid solubility
C. High gastrointestinal enzyme activity and low mucosal permeability
D. Slow renal clearance
Answer: C
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10. The main causes for poor systemic bioavailability of orally administered protein drugs are:
A. Poor taste and solubility
B. Gastrointestinal bleeding and nausea
C. High enzyme activity and low membrane permeability
D. Poor liver metabolism
Answer: C
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3May 24, 2025 1.1K 4
