New MRI‑visible brain aging marker identified: choroid plexus calcification linked to metabolic risks
A preprint from 16 September analysed 30,012 MRI scans from the UK Biobank, measuring choroid plexus calcification with quantitative susceptibility mapping (QSM). Calcification rose with age and was higher in men than women.
The strongest association was found in the third ventricle, where calcification correlated most tightly with diabetes, obesity, smoking, hypertension and ischemic heart disease, even after adjusting for ventricular volume. This pattern was weaker in the
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PubMed Central (PMC)
Age-related Vascular Alterations in the Choroid Plexus: Novel Insights from Pathophysiology and Imaging Studies
The choroid plexus (ChP), a highly vascularized brain structure responsible for cerebrospinal fluid (CSF) production, undergoes significant age-related changes that may contribute to neurodegenerative diseases involving disrupted immune regulation, ...
September 22, 2026 9
