We are happy to share our new paper in Nucleic Acids Research! "Boolean logic links chromatin accessibility states to gene expression variability across cell types" We developed ocrRBBR, a computational framework that decodes combinatorial cis-regulatory logic from paired ATAC-RNA data. Instead of simple correlations, ocrRBBR infers interpretable Boolean rules like: (¬OCR_A ∧ OCR_B) or (OCR_A ∧ OCR_B) These rules capture everything from synergistic enhancer interactions to redundant/additive logic, explaining how OCR combinations drive cell-type-specific gene expression. Key findings: - Cell-type-specific genes rely on selective Boolean rules integrating signals from more OCRs (including distal enhancers) - Housekeeping genes use simpler, modular rules with fewer OCRs - Cell-type-specific rules enrich for lineage-defining pathways - This provides a mechanistically interpretable framework linking chromatin accessibility to gene regulation! Full paper link: https://academic.oup.com/nar/article/54/6/gkag230/8558641
