Prosthetic valve IE
Valve dysfunction causing heart failure
Uncontrolled infection (e.g., enlarging vegetation, persistent bacteremia)
Perivalvular extension or complications (e.g., abscess, pseudoaneurysm, fistula, heart block)
IE due to difficult to treat organisms (e.g., fungi, MDRO)
High embolic risk (e.g., mobile vegetation ≥ 10 mm, recurrent embolism)