The Hidden Bottleneck: Purification
Synthesising the peptide is only half the job.
The crude peptide then needs:
🔸Preparative HPLC
🔸Chromatography
🔸Isolation
🔸Lyophilisation
For some processes, purification can contribute ~50–60% of manufacturing cost.
So the real question isn't just:
How much SPPS capacity does a company have?
It is:
Can it purify complex peptides economically at scale?
1September 3, 2026 1.2K 6