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EGQ LIFE SCIENCE: post #446 — TG.ME

EGQ LIFE SCIENCE@egqlifescience · 879 subscribers Open in TelegramOpen

t.me/egqlifescience/446

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January 9, 2025 1.7K 3

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Complete Microbiology PYQs from 2010 to 2024. 1.5K·Jan 12 ⭐️ Agar aapko PYQ's upyogi lag rahe hain, to kripya Play Store pe app ko rating dijiye. Dhanyavaad! https://bit.ly/EGQLIFESCIENCE 1.5K·Jan 12 🔴 GATE Microbiology ka sirf 2024 ka paper hi baaki hai, jo aaj complete ho jayega. 1.5K·Jan 12 ✅ TRANSLOCATION IN PROTEIN SYNTHESIS: (Important concept) • Translocation is a crucial step during the elongation phase of protein synthesis. It involves the movement of the mRNA and the peptidyl-tRNA (the tRNA carrying the growing peptide chain) by one codon through the ribosome. • This movement shifts the tRNA from the A site (aminoacyl site) to the P site (peptidyl site) and the empty tRNA from the P site to the E site (exit site), making the A site available for the next aminoacyl-tRNA. • Role of GTP and EF-G in E. coli: • In E. coli, translocation requires the elongation factor G (EF-G) and the hydrolysis of GTP (guanosine triphosphate). • EF-G binds to the ribosome and, upon GTP hydrolysis, undergoes a conformational change that drives the translocation process, moving the mRNA and tRNAs to their new positions. • In Vitro Translocation: • Interestingly, in vitro studies have shown that translocation can occur without GTP and EF-G. This suggests that the ribosome itself has an inherent ability to facilitate translocation, although this process is significantly slower and less efficient compared to in vivo conditions. 1.7K·Jan 3

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