An 18 year old woman with a BMI of 31 kg/m2 attends her family physician with troublesome hirsutism, acne and irregular periods. Hyperandrogenism as a sequela of polycystic ovary syndrome (PCOS) may result from which of the following?
A. Genetic mutation in 3β-hydroxysteroid dehydrogenase
B. Higher FSH compared with LH synthesis by the pituitary gland
C. Increased pulsatility of GnRH
D. Reduced aromatisation of androgens by
theca cells
E. Reduction in circulating SHBG
June 17, 2022 6.3K 8
