We need to translate Russian news post into natural English, format per rules.
First line: short headline under 90 chars, no markdown, no '#'.
Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines.
Wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence.
Wrap study/journal citations and publication references in single underscores (e.g. Nature Aging, July 2026).
We must preserve all facts, numbers, names, citations exactly. No commentary.
We need to decide which facts to bold: key numbers: median lifespan 1.64 years vs 2.01 years; 76 mice vs 99 controls; date 25 August 2026; maybe 18-month mice; 9 months ovarian fibrosis; 1,392 stronger opened sites; 84 families repeats reduced methylation; maybe drug RU.521; STING; PYHIN; etc. But we can only bold at most 4-5 facts. Choose the most important: median lifespan numbers, mouse numbers, date, maybe 18-month frailty index, 1,392 opened sites, 84 families methylation. That's 6; need max 5. Let's pick: median lifespan (1.64 vs 2.01), mouse numbers (76 vs 99), date (25 August 2026), 18‑month frailty index increase, 1,392 opened chromatin sites. That's 5.
We must ensure bold formatting only around those specific numbers/phrases, not whole sentences. Eg 1.64 years vs 2.01 years; 76 mice vs 99 controls; 25 August 2026; 18‑month; 1 392 opened sites. Ensure not bold whole sentence.
Citations: need underscores for study/journal citations and publication references. The article is Nature Aging, published 25 August 2026. So we wrap Nature Aging, August 2026 maybe. The text says "опубликованной 25 августа 2026 года статье Nature Aging". So citation: Nature Aging, August 2026. Also maybe mention "мартовской работе о PEP" but that's a reference; we could underscore that as well? But we should limit underscores to citations; we can include both: Nature Aging, August 2026 and March 2026 PEP study maybe. However we need to preserve facts exactly; we can include underscores around the journal name and date. The phrase "мартовской работе о PEP" is a citation; we could underscore that as March 2026 PEP study. But we need to be careful not to overdo. Probably just one citation is enough: the main article. The instruction: "Wrap study/journal citations and publication references in single underscores". So we should wrap any such references. There's also "мартовской работе о PEP". That is a reference to a March work about PEP. We'll underscore that as March 2026 PEP study. Also maybe "Nature Aging, August 2026". That's two underscores.
We must not add any extra commentary.
Now produce headline: something like "Loss of cGAS disrupts genome packaging, activates LINE1 and shortens mouse lifespan". Count characters: Let's count: "Loss of cGAS disrupts genome packaging, activates LINE1 and shortens mouse lifespan". Count: L(1) o2 s3 s4 space5 o6 f7 space8 c9 G10 A11 S12 space13 d14 i15 s16 r17 u18 p19 t20 s21 space22 g23 e24 n25 o26 m27 e28 space29 p30 a31 c32 k33 a34 g35 i36 n37 g38 ,39 space40 a41 c42 t43 i44 v45 a46 t47 e48 s49 space50 L51 I52 N53 E54 1 55 space56 a57 n58 d59 space60 s61 h62 o63 r64 t65 e66 n67 s68 space69 m70 o71 u72 s73 e74 space75 l76 i77 f78 e79 s80 p81 a82 n83. That's 83 characters, under 90. Good.
Now blank line.
Now body paragraphs, each 2-3 sentences.
We need to incorporate the facts with bold and underscores.
Let's draft paragraphs.
Paragraph 1: Introduce study: In mice lacking cGAS, genome packaging was disrupted, LINE1 mobile elements activated, and lifespan shortened. In a Nature Aging, August 2026 article, researchers compared 76 mice with genetically knocked‑out cGAS to 99 controls; median lifespan was 1.64 years versus 2.01 years.…
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Nature
cGAS-deficient mice display premature aging associated with derepression of LINE1 elements and inflammation
Nature Aging - Demonstrating a role for cyclic GMP–AMP synthase (cGAS) in chromatin organization, Martinez, Morandini and colleagues report that cGAS-knockout mice exhibit compromised...
