AI Model Helps Find Gene
Researchers combined an AI model with data on gene activity in individual blood stem cells, genetic regulator testing, and cell transplantation in mice. They found that the Pbx1 gene is involved in the age-related shift: after transplantation, old cells are less effective at restoring erythrocytes and more likely to produce thrombocyte precursors.
The study, published on August 21 in Science Advances, used the Geneformer AI model to identify the Pbx1 gene as a key regulator of this shift. The model was trained on ten datasets of young and old mouse HSC cells and used to predict which genes, when activated, would make young cells resemble old cells.
The team then tested the prediction in cells by activating 143 genetic regulators associated with blood formation in young HSC cells and tracking the CD48 marker. They found that increased Pbx1 activity slowed the appearance of CD48, and that its activity was higher in old HSC cells.
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PubMed Central (PMC)
Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging
Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain ...
August 24, 2026 7
